4.6 Review

Bispecific T-cell engagers for treatment of multiple myeloma

Related references

Note: Only part of the references are listed.
Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy

Kinan Alhallak et al.

Summary: This study developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs) and nanoparticles targeting multiple cancer antigens (nanoMuTEs), overcoming the major limitations of current T-cell-based immunotherapy. These novel nanoparticles have a long half-life, enabling once-a-week administration while maintaining efficacy, with nanoMuTEs targeting multiple cancer antigens showing greater efficacy in myeloma cells.

LEUKEMIA (2021)

Article Medicine, General & Internal

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

Nikhil C. Munshi et al.

Summary: The phase 2 study confirmed the efficacy and safety of ide-cel in patients with relapsed and refractory myeloma, with a majority of patients achieving responses and 26% achieving MRD-negative status. Despite the high response rate, almost all patients experienced grade 3 or 4 toxic effects, including hematologic toxic effects and cytokine release syndrome.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Oncology

The Immune Microenvironment in Multiple Myeloma: Friend or Foe?

Raquel Lopes et al.

Summary: The interaction between multiple myeloma and immune cells in the bone marrow microenvironment is considered a key aspect of this hematological disease. Understanding how myeloma cells disrupt immune homeostasis is crucial in developing effective treatments, particularly through immunotherapy. Ongoing pre-clinical studies are focused on targeting immune populations within the bone marrow niche, aiming to improve outcomes for patients with multiple myeloma.

CANCERS (2021)

Article Hematology

A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

David J. DiLillo et al.

Summary: CD3-engaging bispecific antibodies and CAR T cells are effective therapeutic approaches for treating tumors by redirecting T cells. A fully human bispecific antibody (REGN5458) was introduced, showing potent antitumor activities against MM. In comparison to anti-BCMA CAR T cells, this bsAb demonstrated rapid clearance of MM tumors in animal models, suggesting differences in therapeutic mechanisms.

BLOOD ADVANCES (2021)

Meeting Abstract Oncology

ISB 1342: A first-in-class CD38 T cell engager for the treatment of relapsed refractory multiple myeloma.

Marie-Agnes Doucey et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Medicine, General & Internal

Teclistamab, a B-cell maturation antigenxCD3 bispecific antibody, in patients with relapsed or refractory multiple myeloma (MajesTEC-1): a multicentre, open-label, single-arm, phase 1 study

Saad Z. Usmani et al.

Summary: The study evaluated the safety, tolerability, and efficacy of the novel therapy teclistamab for relapsed or refractory multiple myeloma. The results showed promising response rates and durable efficacy in patients treated at the recommended phase 2 dose, with good overall safety profiles.

LANCET (2021)

Article Medicine, General & Internal

Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial

Philippe Moreau et al.

Summary: The study showed that the addition of isatuximab to carfilzomib-dexamethasone significantly improves progression-free survival and depth of response in patients with relapsed multiple myeloma, representing a new standard of care for this patient population.

LANCET (2021)

Article Medicine, General & Internal

Ciltacabtagene autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study

Jesus G. Berdeja et al.

Summary: The study aimed to evaluate the safety and clinical activity of cilta-cel in patients with relapsed or refractory multiple myeloma, and the results showed that cilta-cel treatment achieved good efficacy and safety with short treatment duration, deep response, and long duration of response.

LANCET (2021)

Article Oncology

Anti-B-Cell Maturation Antigen BiTE Molecule AMG 420 Induces Responses in Multiple Myeloma

Max S. Topp et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Cell Biology

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

Eric L. Smith et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Hematology

PD-L1, LAG3, and HLA-DR are increasingly expressed during smoldering myeloma progression

Alberto Mussetti et al.

ANNALS OF HEMATOLOGY (2019)

Review Pharmacology & Pharmacy

A review of bispecific antibodies and antibody constructs in oncology and clinical challenges

Frans V. Suurs et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Article Oncology

Managing the toxicities of CAR T-cell therapy

Sattva S. Neelapu

HEMATOLOGICAL ONCOLOGY (2019)

Article Oncology

Anti-GPRC5D/CD3 Bispecific T-Cell-Redirecting Antibody for the Treatment of Multiple Myeloma

Tatsushi Kodama et al.

MOLECULAR CANCER THERAPEUTICS (2019)

Article Medicine, General & Internal

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma

Ajai Chari et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Hematology

ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells

Daniel W. Lee et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2019)

Article Immunology

Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Starlynn C. Clarke et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Medicine, General & Internal

Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated Myeloma

M. -V. Mateos et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Genetics & Heredity

Dissecting the multiple myeloma-bone microenvironment reveals new therapeutic opportunities

G. Shay et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

Article Medicine, General & Internal

Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma

M. A. Dimopoulos et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma

Antonio Palumbo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Oncology

Multiple myeloma epidemiology and survival: A unique malignancy

Dickran Kazandjian

SEMINARS IN ONCOLOGY (2016)

Article Multidisciplinary Sciences

γ-secretase directly sheds the survival receptor BCMA from plasma cells

Sarah A. Laurent et al.

NATURE COMMUNICATIONS (2015)

Article Oncology

B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma

Robert O. Carpenter et al.

CLINICAL CANCER RESEARCH (2013)

Article Medicine, General & Internal

Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma

Johanna Atamaniuk et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Biotechnology & Applied Microbiology

Advances in the assessment and control of the effector functions of therapeutic antibodies

Xu-Rong Jiang et al.

NATURE REVIEWS DRUG DISCOVERY (2011)