Journal
ALZHEIMERS & DEMENTIA
Volume 19, Issue 3, Pages 924-932Publisher
WILEY
DOI: 10.1002/alz.12725
Keywords
blood pressure; brain age; brain imaging; cognition; longitudinal; magnetic resonance imaging; mid-life; risk factors
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We found that elevated blood pressure from early to mid-adulthood is associated with advanced brain aging in mid-life, even if the blood pressure is below the clinical cutoffs.
Background High blood pressure (BP) is a risk factor for late-life brain health; however, the association of elevated BP with brain health in mid-life is unclear. Methods We identified 661 participants from the Coronary Artery Risk Development in Young Adults Study (age 18-30 at baseline) with 30 years of follow-up and brain magnetic resonance imaging at year 30. Cumulative exposure of BP was estimated by time-weighted averages (TWA). Ideal cardiovascular health was defined as systolic BP < 120 mm Hg, diastolic BP Every 5 mmHg increment in TWA systolic BP was associated with approximately 1-year greater brain age (95% confidence interval [CI]: 0.50-1.36) Participants with TWA systolic or diastolic BP over the recommended guidelines for ideal cardiovascular health, had on average 3-year greater brain age (95% CI: 1.00-4.67; 95% CI: 1.45-5.13, respectively). Conclusion Elevated BP from early to mid adulthood, even below clinical cut-offs, is associated with advanced brain aging in mid-life.
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