Journal
ALZHEIMERS & DEMENTIA
Volume 19, Issue 3, Pages 946-955Publisher
WILEY
DOI: 10.1002/alz.12721
Keywords
Alzheimer's disease; cognitive impairment; Framingham Heart Study; natural language processing; neuropsychological tests
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This study developed a natural language processing approach to assess different stages of dementia based on automated transcription of digital voice recordings of neuropsychological tests. The results showed that this approach performed well in identifying mild cognitive impairment and dementia, providing potential for developing remote screening tools.
Introduction Automated computational assessment of neuropsychological tests would enable widespread, cost-effective screening for dementia. Methods A novel natural language processing approach is developed and validated to identify different stages of dementia based on automated transcription of digital voice recordings of subjects' neuropsychological tests conducted by the Framingham Heart Study (n = 1084). Transcribed sentences from the test were encoded into quantitative data and several models were trained and tested using these data and the participants' demographic characteristics. Results Average area under the curve (AUC) on the held-out test data reached 92.6%, 88.0%, and 74.4% for differentiating Normal cognition from Dementia, Normal or Mild Cognitive Impairment (MCI) from Dementia, and Normal from MCI, respectively. Discussion The proposed approach offers a fully automated identification of MCI and dementia based on a recorded neuropsychological test, providing an opportunity to develop a remote screening tool that could be adapted easily to any language.
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