HERACLIS-TAF: a multicentre prospective cohort study on 2-year safety and efficacy of tenofovir alafenamide in patients with chronic hepatitis B with renal and/or bone disorders or risks

Article Gastroenterology & Hepatology

Safety and Effectiveness of Tenofovir Alafenamide in Usual Clinical Practice Confirms Results of Clinical Trials: TARGET-HBV

David E. Bernstein et al.

Summary: This study evaluated the characteristics and clinical outcomes of patients treated with TAF in usual clinical practice, showing that TAF is widely utilized and well tolerated with a perceived improved safety profile. Long-term observation of TAF supports its safety and effectiveness.

DIGESTIVE DISEASES AND SCIENCES (2022)

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Article Gastroenterology & Hepatology

Treatment and Renal Outcomes Up to 96 Weeks After Tenofovir Alafenamide Switch From Tenofovir Disoproxil Fumarate in Routine Practice

Hidenori Toyoda et al.

Summary: Following the switch to TAF, patients with chronic hepatitis B showed continued improvement in virologic response and ALT normalization, with no significant changes in estimated glomerular filtration rate. Patients with chronic kidney disease at baseline also showed improvement in kidney function after switching to TAF.

HEPATOLOGY (2021)

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Article Multidisciplinary Sciences

Real-world experience of switching from tenofovir disoproxil fumarate to tenofovir alafenamide in patients with chronic hepatitis B: a retrospective study

Pei-Yuan Su et al.

Summary: The study demonstrated that switching from TDF to TAF resulted in good antiviral efficacy and stabilized renal function. Body weight and BMI decreased during TDF therapy and returned to normal levels after switching to TAF.

PEERJ (2021)

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Article Gastroenterology & Hepatology

Effectiveness and Renal Safety of Tenofovir Alafenamide Fumarate among Chronic Hepatitis B Patients: Real-World Study

Mina S. Farag et al.

Summary: The study confirmed that in patients with chronic hepatitis B, TAF is safer, more effective, and performs well in real-world settings compared to TDF. For patients with compromised kidney function, there is significant improvement in renal function after switching to TAF.

JOURNAL OF VIRAL HEPATITIS (2021)

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Article Gastroenterology & Hepatology