Related references
Note: Only part of the references are listed.
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Summary: This study compared plasma and dried blood spots for the detection of SARS-CoV-2 IgG antibodies. The results showed a good correlation between IgG values measured by both sampling methods, with correlation coefficients of 0.935 and 0.965 for the Receptor Binding Domain and full-length spike protein of SARS-CoV-2, respectively. Bland-Altman assessment also demonstrated good agreement between the two sampling methods. Therefore, dried blood spots are a more pragmatic method for collecting samples for sero-epidemiological surveys of SARS-CoV-2 infection.
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Review
Biochemistry & Molecular Biology
Marta C. Nunes et al.
Summary: COVID-19 caused by the SARS-CoV-2 coronavirus is associated with severe illness in pregnant women and can result in adverse fetal outcomes. Initially, pregnant women were excluded from clinical trials of the COVID-19 vaccines, but they have now been included in the vaccination programs. This review focuses on the safety, immunogenicity, and effectiveness of the mRNA COVID-19 vaccines in pregnant women.
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Summary: Pregnant women are at increased risk of contracting COVID-19, especially those with chronic comorbidities like HIV and pre-eclampsia. The relationship between COVID-19 superimposed on HIV infection and pre-eclampsia is complex and requires further research to understand its impact on pregnant women.
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Shuo Feng et al.
Summary: Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine were identified as correlates of protection against symptomatic infection. Higher levels of immune markers were correlated with a reduced risk of symptomatic infection. The data can be used to extrapolate efficacy estimates to new populations.
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Hector Zambrano et al.
Summary: The study found a high incidence of SARS-CoV-2 infection during pregnancy, with maternal antibodies efficiently passed on to the fetus, highlighting the need for active immunization to enhance maternal protection.
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Medicine, General & Internal
L. de Waard et al.
Summary: This study described the clinical presentation and outcomes of a cohort of high-risk pregnant women with COVID-19 in South Africa. The impact of COVID-19 was severe, significantly increasing maternal mortality risk compared with baseline rates, but had limited impact on neonatal outcomes. Virally suppressed HIV infection was not associated with worse COVID-19 outcomes in pregnancy.
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
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Dustin D. Flannery et al.
Summary: Efficient transplacental transfer of SARS-CoV-2 IgG antibodies supports the potential for maternally derived antibodies to provide neonatal protection from SARS-CoV-2 infection. This cohort study assesses the association between maternal and neonatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody concentrations.
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Aljawharah Alrubayyi et al.
Summary: The majority of people living with HIV on ART have detectable adaptive immune responses to SARS-CoV-2, with comparable humoral and T cell responses to HIV-negative subjects. T cell responses against Spike, Membrane and Nucleoprotein are prominent in both groups, with CD4 T cells outnumbering CD8 T cells. The magnitude of SARS-CoV-2-specific T cell responses is related to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in people living with HIV, potentially impacting vaccine effectiveness and individual management.
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Marta C. Nunes et al.
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Acoustics
L. C. Poon et al.
Summary: In pregnant women who have recovered from COVID-19, anti-SARS-CoV-2 IgG concentrations at delivery increased with increasing viral load during infection and decreased with increasing infection-to-delivery interval. The median transplacental transfer ratio of IgG was 1.3 and it decreased with increasing viral load during infection.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
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Immunology
Shabir A. Madhi et al.
Summary: This study aimed to assess the safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine in people with HIV and HIV-negative individuals. The vaccine showed favorable safety and immunogenicity in people with HIV, including heightened immunogenicity in SARS-CoV-2 baseline-seropositive participants.
Review
Medicine, General & Internal
John Allotey et al.
BMJ-BRITISH MEDICAL JOURNAL
(2020)
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Medicine, General & Internal
Andrea G. Edlow et al.
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Immunology
Marta C. Nunes et al.
JOURNAL OF INFECTIOUS DISEASES
(2015)
