DNA methylation-regulated SNX20 overexpression correlates with poor prognosis, immune cell infiltration, and low-grade glioma progression

Article Cell Biology

Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways

Lubomir Minarik et al.

Summary: Through the development of cellular models, researchers identified cancer-related pathways that play a crucial role in the resistance of myelodysplastic syndrome (MDS) cells to hypomethylating agents (HMA) and their progression to acute myeloid leukemia (AML). These pathways can be modulated by specific inhibitors, but do not increase the sensitivity of the cells to HMA.

CELLS (2022)

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Article Biochemistry & Molecular Biology

The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC

Xiaosong Wang et al.

Summary: The study revealed that circACTN4 is upregulated in breast cancer tissues and cells, promoting tumor growth, invasion, and metastasis, and correlating with clinical stage and prognosis. circACTN4 interacts with FUBP1 to activate MYC transcription, facilitating breast cancer progression.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

SNX20AR/MiRNA-301a-3p/SNX20 Axis Associated With Cell Proliferation and Immune Infiltration in Lung Adenocarcinoma

Yixiao Yuan et al.

Summary: Studies have shown that SNX20 is down-regulated in lung adenocarcinoma, correlated with poor prognosis and immune cell infiltration in lung cancer, over-expression of SNX20 can inhibit NSCLC cell proliferation and migration, and the decrease of SNX20 may be caused by DNA hypermethylation.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Biotechnology & Applied Microbiology