Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 364, Issue 20, Pages 3600-3606Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202200537
Keywords
quinazoline; sulfur-mediated; metal -; solvent-free; derivative; photophysical properties
Categories
Funding
- National Natural Science Foundation of China [21961016]
- Hengyang Normal university Science Fund Project [2020QD07]
- Natural Science Foundation of Jiangxi Province of China [20202BAB203003]
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A strategy for the synthesis of quinazolines via elemental sulfur-mediated oxidative condensation of nitriles and 2-(aminomethyl)anilines was developed. This metal-/solvent-free reaction tolerates a wide range of functional groups and provides the corresponding products in high yield, making it suitable for gram-scale reactions. The photophysical properties of several product derivatives were studied through UV/Vis absorption and fluorescence spectra analysis.
A strategy for the synthesis of quinazolines via elemental sulfur-mediated oxidative condensation of nitriles and 2-(aminomethyl)anilines was developed. The reaction was carried out under metal-/solvent-free conditions, tolerates a wide range of functional groups to provide the corresponding products in 56%-91% yield, and can be performed on a gram-scale. The UV/Vis absorption and fluorescence spectra of several product derivatives were measured to study their photophysical properties.
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