4.7 Article

One Pot Synthesis of 1,2-Disubstituted Ethanones by Base-Mediated Reductive Homocoupling of Aldehydes

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 364, Issue 17, Pages 2951-2956

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202200586

Keywords

Ethanones; Aldehydes; Base; One Pot; Reductive Homocoupling

Funding

  1. National Natural Science Foundation of China [22002067]
  2. Hundred-Talent Program of CAS
  3. Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province [20220052]
  4. Natural Science Foundation of Shanxi Province of China [202103021223457]
  5. State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, CAS [2021BWZ011]

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Reductive homocoupling transformations mediated by bases and TMSCN have been utilized for the synthesis of 1,2-disubstituted ethanones. This protocol offers a method for the synthesis of functionalized ethanones from aldehydes without the need for transition metals, all in a single reaction vessel.
Reductive homocoupling transformations mediated by bases and TMSCN have been used as a strategy for synthesis of 1,2-disubstituted ethanones. This protocol provides a method for synthesizing functionalized ethanones from aldehydes in one pot without transition metals.

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