Journal
ADVANCED POWDER TECHNOLOGY
Volume 33, Issue 8, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apt.2022.103684
Keywords
Budesonide pellets; Conventional pellets; Liqui-pellets; Solid dispersion pellets; Dissolution rate
Categories
Funding
- Vice Chancellor for Research and Technology of Mashhad University of Medical Sciences, Mashhad, Iran (MUMS) [981658]
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The current research explores different approaches to improve the dissolution rate of budesonide in pellet formulations. The method of layering budesonide solid dispersion on placebo pellets (LSDP) shows the most promising results for achieving high dissolution rate.
The current research attempts different approaches to overcome the poor dissolution of budesonide (a poorly water-soluble drug) from pellet formulations. Various methods such as liqui-pellet (LP) and pellets made of solid dispersion (SDP) were employed and compared to conventional pellets (CP). In SDP method, budesonide:PVP solid dispersion was prepared followed by extrusion-pelletization. Solid disper-sion of budesonide-PVP was also layered to the surface of placebo pellets (LSDP). In LP technique, budes-onide dispersed in PEG 400 was mixed with Avicel or Avicel:lactose and was extruded-spheronized. Pellets were evaluated for their shape, size, mechanical properties and dissolution rate. The pellets made by LSDP method were significantly harder than CP or PSDP. LP with a loading factor greater than 0.34 was very soft compared to CP and SDP. Pelletization of budesonide SD (PSDP) did not have a tremendous effect on the dissolution enhancement of budesonide compared to CP whilst LSDP showed faster drug release. In conclusion, the layering of budesonide solid dispersion on placebo pellets (LSDP) was the most promising approach for the production of pellets with the highest dissolution rate so that more than 80% of the drug was released within the first 5 min. Also this formulation had proper mechanical properties. This method has the capability to overcome the poor dissolution of budesonide associated with the pellet containing Avicel, and could be employed for the dissolution enhancement of other poorly water-soluble drugs in pellet form.(c) 2022 The Society of Powder Technology Japan. Published by Elsevier BV and The Society of Powder Technology Japan. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/).
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