miRNAs in the regulation of mTOR signaling and host immune responses: The case of Leishmania infections

Micro RNAs (miRNAs), as regulators of gene expression at the post-transcriptional level, can respond to/or interact with cell signaling and affect the pathogenesis of different diseases/infections. The interaction/crosstalk of miRNAs with various cellular signaling networks including mTOR (as a master regulator of signaling relevant to different cellular mechanisms) might lead to the initiation, progression or restriction of certain disease processes. There are numerous studies that have identified the crosstalk between regulatory miRNA expression and the mTOR pathway (or mTOR signaling regulated by miRNAs) in different diseases which has a dual function in pathogenesis. However, the corresponding information in parasitic infections remains scarce. miRNAs have been suggested as specific targets for therapeutic strategies in several disorders such as parasitic infections. Thus, the targeting of miRNAs (as the modulators/regulators of mTOR) by small molecules and RNA-based therapeutics and consequently managing and modulating mTOR signaling and the downstream/related cell signaling/pathways might shed some light on the design of new therapeutic strategies against parasitic diseases, including Leishmaniasis. Accordingly, the present study attempts to highlight the importance of the crosstalk between regulatory miRNAs and mTOR signaling, and to review the relevant insights into parasitic infections by focusing specifically on Leishmania.

Automated summary

Micro RNAs (miRNAs) play a role in regulating gene expression and can interact with cell signaling, influencing the pathogenesis of different diseases. The crosstalk between miRNAs and cellular signaling networks, including mTOR, can impact disease progression. While there have been studies on the crosstalk between miRNAs and mTOR signaling in various diseases, research on parasitic infections is limited. Targeting miRNAs as regulators of mTOR could provide new therapeutic strategies against parasitic diseases.