Journal
ACTA BIOMATERIALIA
Volume 151, Issue -, Pages 647-660Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2022.07.049
Keywords
Zn alloy micro-tube; Vascular stent; Microstructure; Texture; Mechanical properties
Funding
- National Key Research and Development Program of China
- National Natural Science Foundation of China
- Shanghai International Joint-Innovation Pro-gram
- Medical-engineering cross fund of Shanghai Jiaotong University, China
- [2018YFE0115400]
- [51971134]
- [20520711700]
- [ZH2018ZDA34]
- [ZH2018QNA60]
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This study successfully fabricated biodegradable zinc alloy micro-tubes and vascular stents with suitable mechanical properties and corrosion behavior, indicating them as promising candidates for vascular stent applications.
Zinc (Zn) alloys are a promising biodegradable material for vascular stent applications. This study aimed to fabricate biodegradable Zn-2.0Cu-0.5Mn alloy micro-tubes and vascular stents with high dimensional accuracy and suitable mechanical properties, and to investigate their microstructure, texture, mechanical properties and corrosion behavior. The micro-tubes and vascular stents were successfully fabricated by a combined process of extrusion, drawing, laser cutting and electrochemical polishing. The microstruc-tures of as-extruded and as-drawn micro-tubes consisted of Zn matrix with near-equiaxed grains (aver-age grain size: similar to 2 pm) and second phases of epsilon (CuZn4) and MnZn13 with different sizes. The texture evolved from basal planes approximately paralleling to deformation direction for as-extruded micro-tube to approximately perpendicular to deformation direction for as-drawn micro-tube, because predominant deformation mechanisms changed from basal < a > dislocation slip during tube extrusion to prismatic < a > dislocation, pyramidal < c + a > dislocations, and { 10 1 over bar 2 } twins during tube drawing. As-drawn micro -tube exhibited suitable mechanical properties with an ultimate tensile strength of about 298 MPa and elongation of about 26% as a stent material. Moreover, the processed stent with a thickness of about 125 pm possessed sufficient radial strength of about 150 kPa and good balloon expandability. In addi-tion, as-drawn tube exhibited an in vitro corrosion rate of about 158 pm/year with a basically uniform corrosion morphology. These results indicated that biodegradable Zn-2.0Cu-0.5Mn alloy is a promising vascular stent material candidate, and the procedure for processing the micro-tube and stent is practical and effective.
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