Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 54, Issue 8, Pages 1049-1056Publisher
SCIENCE PRESS
DOI: 10.3724/abbs.2022088
Keywords
detergent; micelle; nanodiscs; cryo-EM; membrane protein
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Funding
- National Key R&D Program of China [2017YFA0506300]
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This review discusses the widely-used detergents and their properties and structures in membrane protein structure determination, and also explores the growing interest in membrane mimetic systems in cryo-EM studies, providing insights into the role of detergent alternatives in structure determination.
Structure determination of membrane proteins has been a long-standing challenge to understand the molecular basis of life processes. Detergents are widely used to study the structure and function of membrane proteins by various experimental methods, and the application of membrane mimetics is also a prevalent trend in the field of cryo-EM analysis. This review focuses on the widely-used detergents and corresponding properties and structures, and also discusses the growing interests in membrane mimetic systems used in cryo-EM studies, providing insights into the role of detergent alternatives in structure determination.
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