4.8 Article

Fluidity-Guided Assembly of Au@Pt on Liposomes as a Catalase-Powered Nanomotor for Effective Cell Uptake in Cancer Cells and Plant Leaves

Journal

ACS NANO
Volume 16, Issue 6, Pages 9019-9030

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c00327

Keywords

assembly; fluidity; liposome; lipid phase; nanomotor

Funding

  1. National Natural Science Foundation of China [31971314]
  2. Distinguished Youth Foundation of Anhui Province [1808085J05]
  3. Fundamental Research Funds for the Central Universities of China [JZ2017HGPA0164, JZ2021HGTB0120]
  4. Key Research and Development Plan of Anhui Province [202104b11020015]

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In this study, a liposomal nanomotor system was developed by controlling the self-assembly behavior of gold core-platinum shell nanoparticles on liposomes. This system showed high catalase-like activity and promoted the decomposition of H2O2, leading to enhanced cellular uptake in cancer cells and plant leaves. These findings are important for biomedical and plant nanotechnology research.
The fluidity of the liposomes is essential to nanoparticle-membrane interactions. We herein report a liposomal nanomotor system by controlling the self-assembly behavior of gold core-platinum shell nanoparticles (Au@Pt) on liposomes. Au@Pt can aggregate immediately on fluid-phase dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes, forming an uneven distribution. By control of the lipid phase and fluidity, either using pure 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) above its phase transition temperature or adding cholesterol as an adjuvant to DPPC lipids, we precisely control the assembly of Au@Pt on liposomes. Au@Pt maintained high catalase-like activity on the liposomal surface, promoting the decomposition of H2O2 and the movement of the liposomal nanomotors. Finally, we demonstrate that liposomal nanomotors are biocompatible and they can speed up the cellular uptake in mammalian HepG2 cancer cells and Nicotiana tabacum (Nb) plant leaves. This liposomal nanomotor system is expected to be further investigated in biomedicine and plant nanotechnology.

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