Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 24, Pages 28289-28300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c05953
Keywords
covalent organic framework; photothermal therapy; photodynamic thcrapy; peroxidase-like nanozyme activity; synergistic antimicrobial activities
Funding
- National Natural Science Foundation of China [21964011, 22166024, 22064001, 22036003, 21976077, 22176082, 81972020]
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A covalent organic framework called TAPP-BDP with a conjugated donor-acceptor structure has been developed for efficient photoinduced bacteriostasis. It demonstrates triple and synergistic bacterial inhibition through integration of photodynamic, photothermal, and peroxidase-like enzymatic activities under irradiation with near-infrared light. TAPP-BDP exhibits excellent antibacterial efficiency against both Gram-negative and Gram-positive bacteria.
Bacterial infection causes serious threats to human life, especially with the appearance of antibiotic-resistant bacteria. Phototherapeutic approaches have become promising due to their noninvasiveness, few adverse effects, and high efficiency. Herein, a covalent organic framework (TAPP-BDP) with a conjugated donor-acceptor (D-A) structure has been constructed for efficient photoinduced bacteriostasis. Under the irradiation with a single near-infrared (NIR) light (lambda = 808 nm), TAPP-BDP alone involves triple and synergistic bacterial inhibition based on the integration of photodynamic, photothermal, and peroxidase-like enzymatic activities. The unique D-A structure endows TAPP-BDP with a narrow energy band gap, improving its photodynamic and nanozyme activities to generate reactive oxygen species (ROS) to realize the broad-spectrum bactericidal activity. The extended pi-conjugated skeleton of TAPP-BDP results in enhanced absorption in NIR, and the remarkable photothermal activity can increase the temperature up to 65 degrees C to cause efficient bacterial degeneration. TAPP-BDP shows excellent antibacterial efficiency against both Gram-negative and Gram-positive bacteria. Animal experiments further suggest that TAPP-BDP can effectively heal wounds infected with Staphylococcus aureus in living systems.
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