Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 27, Pages 31085-31098Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c05642
Keywords
yeast microcapsule; natural products; anti-inflammation; ulcerative colitis; macrophage polarization
Funding
- National Natural Science Foundation of China [81673374, 32101144]
- Program for HUST Academic Frontier Youth Team [2018QYTD13]
- Natural Science Foundation of Hubei Province [2020CFB301]
Ask authors/readers for more resources
This study designed a macrophages-targeting oral drug delivery system for ulcerative colitis, using berberine and Epigallocatechin Gallate encapsulated in yeast microcapsules. The system effectively transported the drugs to inflammation sites and exerted anti-inflammatory effects through the interaction with macrophage receptors. It provided a new targeting strategy for UC treatment.
ABSTRACT: The common and frequent disease, ulcerative colitis macrophages have proven to play a role in anti-inflammation, which is a new potential target for UC therapy. In this study, we designed a safe and macrophages-targeting oral drug delivery system. Natural products, berberine (BBR), and Epigallocatechin Gallate (EGCG) with anti-inflammatory activity were assembled and encapsulated into yeast microcapsule (YM), generating therapeutic system BBR/MPN@YM. BBR and EGCG exhibited synergistic effects against UC through the effect of antioxidation. Through the interaction between beta-1,3-D-glucan on the surface of YM and dectin-1 receptors on macrophages, BBR/MPN@YM could be effectively transported to inflammation parts and internalized into macrophages, avoiding gastric degradation. In the in vivo UC mouse model, BBR/MPN@YM could transform M1 macrophages into anti-inflammatory M2 macrophages, thus exerting specific anti-inflammatory effects. Therefore, this BBR/ MPN@YM targeted oral drug delivery system provided a new macrophages-targeting strategy for the clinical treatment of UC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available