Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 25, Pages 29238-29249Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c05736
Keywords
multifunctional nanorobot; heavy metal detoxification; liver repair; fluorescence imaging; POSS; organic-inorganic hybrid
Funding
- National Natural Science Foundation of China [21771036, 21671037, 81560407]
- Fujian Provincial Department of Science and Technology [2017J06019]
- China Postdoctoral Science Foundation [2021TQ0204]
- Zhejiang Provincial Natural Science Foundation of China [LGC22H160012]
- project of Taizhou Science and Technology Bureau [1901ky46]
- Zhejiang Provincial Health Planning Commission Fund [2020389903]
Ask authors/readers for more resources
The developed intelligent bionanorobot can recognize and remove zinc ions from poisoned cells, restore cell morphology, and inhibit persistent liver enlargement.
Nanorobots hold great promise for integrated drug delivery systems that are responsive to molecular triggers. Herein, we successfully developed an automatic smart bionanorobot that has transport capability and recognizes and removes zinc ions from poisoned cells based on nanoscale polyhedral oligomeric silsesquioxane molecules. This intelligent bionanorobot can easily move inside and outside the cell and find zinc ions owing to its highly selective recognition to zinc ions and high cell permeability, especially the well-combined high penetration and strong binding energy. More importantly, it was also found that this intelligent bionanorobot can restore round HeLa cells to a normal fusiform cell morphology following high-concentration zinc treatment and does not interfere with cell proliferation and division. It was also shown by in vivo experiments that the bionanorobot can inhibit persistent enlargement of the liver caused by zinc ion poisoning.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available