Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 24, Issue -, Pages 155-156Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2015.07.020
Keywords
Adrenoleukodystrophy; Cannabinoids; Leukodystrophies; MRI; Seizures
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We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed the diagnosis. We hypothesize that cannabinoid use might have contributed to metabolic decompensation with subacute worsening of the underlying condition. (C) 2015 Elsevier Ltd. All rights reserved.
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