Invasive central nervous system aspergillosis in a patient with Crohn's disease after treatment with infliximab and corticosteroids

Aspergillus species are emerging as a significant cause of pneumonia mortality in immune compromised hosts, with haematological spread being a rare and life-threatening complication. The central nervous system (CNS) as a site for extrapulmonary spread is rarer still. We report a case of CNS disseminated aspergillosis in a patient treated with corticosteroids and infliximab, an immunomodulatory agent commonly used in the treatment of inflammatory bowel disease, and review the available literature regarding this rare pathology. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.