Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 55, Issue 2, Pages 360-368Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01057-16
Keywords
diagnostics; gene expression
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Funding
- NIA NIH HHS [P30 AG028716] Funding Source: Medline
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Emerging pandemic infectious threats, inappropriate antibacterial use contributing to multidrug resistance, and increased morbidity and mortality from diagnostic delays all contribute to a need for improved diagnostics in the field of infectious diseases. Historically, diagnosis of infectious diseases has relied on pathogen detection; however, a novel concept to improve diagnostics in infectious diseases relies instead on the detection of changes in patterns of gene expression in circulating white blood cells in response to infection. Alterations in peripheral blood gene expression in the infected state are robust and reproducible, yielding diagnostic and prognostic information to help facilitate patient treatment decisions.
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