4.7 Article

Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 54, Issue 5, Pages 1388-1390

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.03142-15

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Funding

  1. Wellcome Trust [093804, 098532, 087646/Z/08/Z]
  2. Health Innovation Challenge Fund [HICF-T5-358, WT098615/Z/12/Z]
  3. Department of Health
  4. United Kingdom Clinical Research Collaboration
  5. Medical Research Council [G0800778]
  6. Biotechnology and Biological Sciences Research Council
  7. National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
  8. Wellcome Trust [087646/Z/08/Z] Funding Source: Wellcome Trust

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Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.

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