Journal
JOURNAL OF CLINICAL EPIDEMIOLOGY
Volume 79, Issue -, Pages 70-75Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinepi.2016.04.014
Keywords
Observational; studies; Comparative effectiveness research; Target trial; Time zero; Immortal time bias; Selection bias
Funding
- NIH [P01 CA134294]
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Many analyses of observational data are attempts to emulate a target trial. The emulation of the target trial may fail when researchers deviate from simple principles that guide the design and analysis of randomized experiments. We review a framework to describe and prevent biases, including immortal time bias, that result from a failure to align start of follow-up, specification of eligibility, and treatment assignment We review some analytic approaches to avoid these problems in comparative effectiveness or safety research. (C) 2016 Elsevier Inc. All rights reserved.
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