Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 101, Issue 1, Pages 232-241Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2015-3351
Keywords
-
Categories
Funding
- Fundacion Patrimonio Comunal Olivarero
- Junta de Andalucia (Consejeria de Salud)
- Diputaciones de Jaen y Cordoba, Centro de Excelencia en Investigacion sobre Aceite de Oliva y Salud
- Ministerio de Medio Ambiente, Medio Rural y Marino
- Gobierno de Espana
- Ministerio de Ciencia e Innovacion [AGL2009-122270, FIS PI10/01041, PI10/02412]
- Ministerio de Economia y Competitividad [AGL2012/39615, PIE14/00005, PIE14/00031, PI13/00619]
- Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia [AGR922]
- Consejeria de Salud, Junta de Andalucia [PI0193/09, PI-0252/09, PI-0058/10]
- Consejeria de Innovacion Ciencia y Empresa [CVI-7450]
- Fondo Europeo de Desarrollo Regional
- Instituto de Salud Carlos III [CP14/00114]
- Instituto de Salud Carlos III
- Junta de Andalucia (Consejeria de Agricultura y Pesca)
- Junta de Andalucia (Consejeria de Innovacion, and Ciencia y Empresa)
Ask authors/readers for more resources
Context: Gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after a specific diet. Objective: The aim was to study the changes in microbiota after 1 year's consumption of a Mediterranean diet (Med diet) or a low-fat, high-complex carbohydrate diet (LFHCC diet) in an obese population. Design: Participants were randomized to receive the Med diet (35% fat, 22% monounsaturated) and the LFHCC diet (28% fat, 12% monounsaturated). Setting and Participants: The study was conducted in 20 obese patients (men) within the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention (CORDIOPREV) study, an ongoing prospective, randomized, opened, controlled trial in patients with coronary heart disease. Main Outcome Measure: We evaluated the bacterial composition and its relationship with the whole fecal and plasma metabolome. Results: The LFHCC diet increased the Prevotella and decreased the Roseburia genera, whereas the Med diet decreased the Prevotella and increased the Roseburia and Oscillospira genera (P = .028, .002, and .016, respectively). The abundance of Parabacteroides distasonis (P = .025) and Faecalibacterium prausnitzii (P = .020) increased after long-term consumption of the Med diet and the LFHCC diet, respectively. The changes in the abundance of 7 of 572 metabolites found in feces, including mainly amino acid, peptide, and sphingolipid metabolism, could be linked to the changes in the gut microbiota. Conclusions: Our results suggest that long-term consumption of the Med and LFHCC diets exerts a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota, increasing the abundance of the Roseburia genus and F. prausnitzii, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available