Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 101, Issue 9, Pages 3306-3315Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2016-1141
Keywords
-
Categories
Funding
- Dutch Heart Foundation [2013T083]
- Erasmus MC
- Erasmus University, Rotterdam, The Netherlands
- Netherlands Organisation for Scientific Research (NWO)
- Netherlands Organisation for Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports
- European Commission (DG XII)
- Municipality of Rotterdam
- Nestle Nutrition (Nestec Ltd.)
- Metagenics Inc.
- AXA
- NWO VENI [91616079]
- Ferring
- Merck-Serono
- Merck SharpeDome
- Organon
- Schering Plough
- Serono
- Auxogyn
- MSD
- Actavis
- COGI
- Dutch Heart Foundation
- Euroscreen
- Finox
- Gedeon-Richter
- OvaScience
- Pantharei Bioscience
- PregLem
- Roche
- Uteron
- Watson Laboratories
Ask authors/readers for more resources
Context: A young age at menopause has been associated with increased cardiovascular disease (CVD) risk. Objective: To compare the cardiovascular risk profile between women with premature ovarian insufficiency (POI) and premenopausal controls of comparable age. Design: Cross-sectional case control study. Setting: Two university medical centers. Participants: Women above 45 years of age who were previously diagnosed with POI (n = 83) and premenopausal population controls of comparable age (n = 266). Main Outcome Measures: Blood pressure, body mass index, waist circumference, electrocardiogram, bilateral carotid intima media thickness, estradiol, T, androstenedione, dehydroepiandrosterone sulfate, SHBG, insulin, glucose, lipids, TSH, free T-4, N-terminal pro-B-type natriuretic peptide, C-reactive protein, uric acid, creatinine, and homocysteine were measured. Potential associations between POI status and subclinical atherosclerosis were assessed. Results: Women with POI exhibited an increased waist circumference (beta = 5.7; 95% confidence interval [CI], 1.6, 9.9), C-reactive protein (beta = 0.75; 95% CI, 0.43, 1.08), free T-4 levels (beta = 1.5; 95% CI, 0.6, 2.4), and lower N-terminal pro-B-type natriuretic peptide (beta = -0.35; 95% CI, -0.62, -0.08), estradiol (beta = -1.98; 95% CI, -2.48, -1.48), T (beta = -0.21; 95% CI, -0.37, -0.06), and androstenedione (beta = -0.54; 95% CI, -0.71, -0.38) concentrations compared to controls, after adjusting for confounders. After adjustment, a trend toward increased hypertension (odds ratio -2.1; 95% CI, 0.99; 4.56) and decreased kidney function was observed in women with POI (creatinine beta = -3.5; 95% CI, -0.05, 7.1; glomerular filtration rate beta = -3.5; 95% CI, -7.5, 0.46). Women with POI exhibited a lower mean carotid intima media thickness (beta = -0.17; 95% CI, -0.21, -0.13) and decreased odds of plaque presence compared to controls (odds ratio = 0.08; 95% CI, 0.03; 0.26). Conclusions: Women with POI exhibited an unfavorable cardiovascular risk profile, including higher abdominal fat, elevated chronic inflammatory factors, and a trend toward increased hypertension and impaired kidney function compared to controls. However, we observed no signs of increased subclinical atherosclerosis inwomenwith POI. Additional studies are required to identify specific determinants of long-term CVD risk in women with POI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available