Journal
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
Volume 59, Issue 2, Pages 107-112Publisher
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
DOI: 10.3164/jcbn.16-31
Keywords
salivary gland; resveratrol; NOD mouse; salivary secretion; Sjogren's syndrome
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Funding
- Japan Society for the Promotion of Science [23390421]
- Grants-in-Aid for Scientific Research [23390421, 15H05013] Funding Source: KAKEN
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Resveratrol is a natural polyphenol produced by plants in response to environmental stress. This compound has been shown to have pharmacological effects against a wide range of diseases including neurological, hepatic, cardiovascular and autoimmune conditions. The non-obese diabetic (NOD) mouse, in which loss of lacrimal and salivary gland function occurs, has been studied as an animal model for Sjogren's syndrome. In this study, we confirmed that administration of resveratrol results in increased secretion of saliva in NOD mice. Although resveratrol enhanced Sirt1 activity, inflammatory cell infiltration was not affected. Moreover, expression of the anti-inflammatory cytokine IL-10 in salivary glands was enhanced in the resveratrol-administered group. Thus, we confirmed a novel therapeutic effect for resveratrol on salivary dysfunction in Sjogren's syndrome.
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