Journal
BMJ CASE REPORTS
Volume 15, Issue 4, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bcr-2022-249766
Keywords
Obstetrics; gynaecology and fertility; Urinary and genital tract disorders; Drugs; endocrine system; Urological cancer; Surgical oncology
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In this case report, a patient with enlarged retroperitoneal nodes and elevated HCG levels during treatment for subfertility with clomiphene citrate is presented. The patient's condition improved after further examinations and follow-up.
In the context of an elevated human chorionic gonadotropin (HCG) with enlarged retroperitoneal nodes and absent testicular tumours, clinicians will consider a diagnosis of extragonadal germ cell tumours. We report the case of a man in his thirties who while on treatment for subfertility with clomiphene citrate was noted to have enlarged retroperitoneal nodes and elevated HCG levels of 75 IU/L. Chemotherapy with bleomycin, etoposide and cisplatin originally planned was deferred when two separate retroperitoneal nodal biopsies returned as benign fibroadipose tissue and HCG levels spontaneously down-trended to 4 IU/L within 4 months of clomiphene citrate discontinuation. Follow-up imaging revealed regression of the retroperitoneal nodes.
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