3.8 Review

Nanoparticles in peripheral nerve regeneration: A mini review

Related references

Note: Only part of the references are listed.
Review Engineering, Biomedical

Regeneration of the peripheral nerve via multifunctional electrospun scaffolds

Nazanin Ghane et al.

Summary: Electrospun scaffolds have shown advantages in nerve tissue regeneration by promoting functional recovery through connecting growth cones of nerve stumps. Factors such as material selection, structure design, surface modification, and neurotrophic factor loading should be considered. This paper reviews the fabrication methods, polymeric materials, and surface modification techniques of aligned nanofibrous scaffolds.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

Article Biochemistry & Molecular Biology

Regeneration of Rat Sciatic Nerve Using PLGA Conduit Containing Rat ADSCs with Controlled Release of BDNF and Gold Nanoparticles

Maliheh Jahromi et al.

Summary: The combination of AuNPs and BDNF encapsulated in chitosan nanoparticles implanted in NGC, along with r-ADSCs, synergistically promotes nerve regeneration, showing potential as a new strategy for peripheral nerve regeneration.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

Article Clinical Neurology

Assessments of regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration: a transected sciatic nerve model in rat

Pouria Ebrahimi-Zadehlou et al.

Summary: The study assessed the regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration in a transected sciatic nerve model in rats. The use of silymarin nanoparticles significantly promoted the recovery of regenerated fibers, increasing the number and diameter of myelinated fibers.

NEUROLOGICAL RESEARCH (2021)

Article Materials Science, Multidisciplinary

Functional nanomaterials in peripheral nerve regeneration: Scaffold design, chemical principles and microenvironmental remodeling

Yun Qian et al.

Summary: The imbalance of neuronal microenvironment is crucial in the process of neural regeneration. Traditional neural-supporting scaffolds lack biomimetic nanotechnology designs and modifications, making them unsatisfactory. Nanomaterial-based scaffolds show better regenerative effects with enhanced biochemical and physicochemical properties.

MATERIALS TODAY (2021)

Article Biochemistry & Molecular Biology

Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?

Holly Gregory et al.

Summary: Efforts to repair severe peripheral nerve injuries have led to promising approaches using biomaterial constructs. Research is focused on developing sophisticated constructs with regenerative agents to facilitate nerve regeneration. The use of natural proteins and synthetic polymers in nerve repair constructs, as well as cell therapy, show potential for successful outcomes in vivo.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Nanoscience & Nanotechnology

Biocompatible Chitin Hydrogel Incorporated with PEDOT Nanoparticles for Peripheral Nerve Repair

Lin Huang et al.

Summary: The nerve guidance conduit (NGC) made of a hydrogel film composed of chitin and conductive PEDOT nanoparticles was found to significantly promote Schwann cell adhesion and proliferation, leading to enhanced nerve regeneration. The composite material also showed similarities in muscle function and axon thickness compared to autografts in rat sciatic nerve defects, indicating its potential in accelerating peripheral nerve restoration.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Biochemistry & Molecular Biology

Chitosan Functionalized Magnetic Nanoparticles to Provide Neural Regeneration and Recovery after Experimental Model Induced Peripheral Nerve Injury

Nadina Liana Pop et al.

Summary: This study evaluated the effects of magnetic nanoparticles functionalized with chitosan (CMNPs) on peripheral nerve injuries using an in vivo experimental model. The results showed that animals treated with CMNPs had a statistically significant functional outcome compared to the control group. Overall, CMNPs appear to be a promising treatment method for peripheral nerve injuries.

BIOMOLECULES (2021)

Review Materials Science, Biomaterials

Electroactive nanomaterials in the peripheral nerve regeneration

Xiangyun Yao et al.

Summary: Severe peripheral nerve injuries pose threats to human life quality, and current clinical treatments have limitations, leading to extensive research on tissue engineering using nanomaterials. The biophysical and biochemical characteristics of nanomaterials play crucial roles in designing regenerative scaffolds for nerve repair, affecting cell survival and progress. Studies emphasize the significant implications of electroactive nanomaterials for regulating primary supporting cells and developing regenerative scaffolds for peripheral nerve tissue engineering.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Materials Science, Biomaterials

Enhanced sciatic nerve regeneration by poly-L-lactic acid/multi-wall carbon nanotube neural guidance conduit containing Schwann cells and curcumin encapsulated chitosan nanoparticles in rat

Hossein Kargar Jahromi et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Biotechnology & Applied Microbiology

Syringic acid delivered via mPEG-PLGA-PLL nanoparticles enhances peripheral nerve regeneration effect

Yaofa Lin et al.

NANOMEDICINE (2020)

Article Biochemistry & Molecular Biology

Application of electrospun polycaprolactone fibers embedding lignin nanoparticle for peripheral nerve regeneration: In vitro and in vivo study

Shahram Amini et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Editorial Material Biotechnology & Applied Microbiology

Recent advances in the use of magnetic nanoparticles to promote neuroregeneration

Alessandro Falconieri et al.

NANOMEDICINE (2019)

Review Pharmacology & Pharmacy

Nanomaterial-Based Approaches for Neural Regeneration

Raluca Ioana Teleanu et al.

PHARMACEUTICS (2019)

Review Biotechnology & Applied Microbiology

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Milad Fathi-Achachelouei et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Review Biotechnology & Applied Microbiology

Magnetic Composite Biomaterials for Neural Regeneration

Jessica L. Funnell et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Review Pharmacology & Pharmacy

Nanotechnology in peripheral nerve repair and reconstruction

Cristiana R. Carvalho et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Review Biotechnology & Applied Microbiology

Nanoscaffolds in promoting regeneration of the peripheral nervous system

Chen Aijie et al.

NANOMEDICINE (2018)

Review Agriculture, Multidisciplinary

Electrospun nanofibres in agriculture and the food industry: a review

Masumeh Noruzi

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2016)

Review Cell Biology

Nanotechnology and bio-functionalisation for peripheral nerve regeneration

Tina Sedaghati et al.

NEURAL REGENERATION RESEARCH (2015)

Review Biotechnology & Applied Microbiology

Past, Present, and Future of Nerve Conduits in the Treatment of Peripheral Nerve Injury

Aikeremujiang Muheremu et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Review Nanoscience & Nanotechnology

Nanomaterials, Inflammation, and Tissue Engineering

Jagannath Padmanabhan et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2015)

Review Chemistry, Multidisciplinary

Nanomaterials design and tests for neural tissue engineering

Gloria A. A. Saracino et al.

CHEMICAL SOCIETY REVIEWS (2013)

Review Critical Care Medicine

FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy

S. Kehoe et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2012)

Article Nanoscience & Nanotechnology

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Ofra Ziv-Polat et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

Letter Clinical Neurology

BIOHYBRID - Biohybrid templates for peripheral nerve regeneration

Claudia Grothe et al.

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2012)

Article Cell & Tissue Engineering

Surgical repair of a 30 mm long human median nerve defect in the distal forearm by implantation of a chitosan-PGA nerve guidance conduit

Jianhui Gu et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2012)

Article Engineering, Biomedical

Magnetic Scaffolds Enriched with Bioactive Nanoparticles for Tissue Engineering

Hadas Skaat et al.

ADVANCED HEALTHCARE MATERIALS (2012)

Review Biochemistry & Molecular Biology

From Lactic Acid to Poly(lactic acid) (PLA): Characterization and Analysis of PLA and Its Precursors

Saara Inkinen et al.

BIOMACROMOLECULES (2011)

Article Engineering, Biomedical

Enhancement of incisional wound healing by thrombin conjugated iron oxide nanoparticles

Ofra Ziv-Polat et al.

BIOMATERIALS (2010)