Journal
THERAPEUTISCHE UMSCHAU
Volume 79, Issue 2, Pages 87-91Publisher
HOGREFE AG-HOGREFE AG SUISSE
DOI: 10.1024/0040-5930/a001333
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Deletion of the long arm of chromosome 5 (del(5q)) is a common anomaly in myelodysplastic syndromes, which has specific pathophysiology and treatment options. MDS patients with isolated del(5q) have a low risk profile and can be treated with lenalidomide. It is important to differentiate isolated del(5q) from MDS with an anomaly on the long arm of chromosome 5 and additional mutations, which are classified as high-risk forms of MDS.
Deletion of the long arm of chromosome 5 (del(5q)) is a recurrent anomaly in myelodysplastic syndromes associated with a distinct pathophysiology and specific treatment options. MDS with isolated del(5q) are associated with a favorable risk profile and can be treated with lenalidomide. MDS with isolated del(q) have to be distinguished from MDS with an anomaly on the long arm of chromosome 5 and more than one additional mutation turning these cases into high-risk forms of MDS.
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