4.6 Article

Flow modulation comprehensive two-dimensional gas chromatography-mass spectrometry using ≈4 mL min-1 gas flows

Journal

JOURNAL OF CHROMATOGRAPHY A
Volume 1441, Issue -, Pages 134-139

Publisher

ELSEVIER
DOI: 10.1016/j.chroma.2016.02.041

Keywords

Flow modulation; Comprehensive two-dimensional gas chromatography; Mass spectrometry; Method optimization

Funding

  1. Shimadzu Corporation
  2. Sigma-Aldrich/Supelco Corporation

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The main objective of the herein described research was focused on performing satisfactory flow modulation (FM), in comprehensive two-dimensional gas chromatography-mass spectrometry (GC x GC-MS), using an MS-compatible second-dimension gas flow of approx. 4 mL min(-1). The FM model used was based on that initially proposed by Seeley et al. [3]. The use of limited gas flows was enabled through fine tuning of the FM parameters, in particular the duration of the re-injection (or flushing) process. Specifically, the application of a long re-injection period (i.e., 700 ms) enabled efficient accumulation-loop flushing with gas flows of about 4 mLmin(-1). It was possible to apply such extended re-injection periods by using different restrictor lengths in the connections linking the modulator to the auxiliary pressure source. FM GC x GC-MS applications were performed on a mixture containing C9-10 alkanes, and on a sample of essential oil. GC x GC-MS sensitivity was compared with that attained by using conventional GC-MS analysis, in essential oil applications. It was observed that signal intensities were, in general, considerably higher in the FM GC x GC-MS experiments. (C) 2016 Elsevier B.V. All rights reserved.

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