Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1436, Issue -, Pages 19-27Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2016.01.053
Keywords
Sample preparation; Frontally eluted components; Matrix effects
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A new concept of using thin-layer chromatography to sample preparation for the quantitative determination of solute/s followed by instrumental techniques is presented Thin-layer chromatography (TLC) is used to completely separate acetaminophen and its internal standard from other components (matrix) and to form a single spot/zone containing them at the solvent front position (after the final stage of the thin-layer chromatogram development). The location of the analytes and internal standard in the solvent front zone allows their easy extraction followed by quantitation by HPLC. The exctraction procedure of the solute/s and internal standard can proceed from whole solute frontal zone or its part without lowering in accuracy of quantitative analysis. (C) 2016 Elsevier B.V. All rights reserved.
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