4.2 Article

The resistance and transmission mechanism of Acinetobacter baumannii isolates in a tertiary care hospital, China

Journal

JOURNAL OF CHEMOTHERAPY
Volume 28, Issue 6, Pages 476-481

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/1120009X.2016.1139335

Keywords

Acinetobacter baumannii; Pulsed-field gel electrophoresis; Resistance; Transmission mechanism

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The aim of this study was to analyse the resistance and epidemiological data of 117 Acinetobacter baumannii isolates from Southwest Hospital, Chongqing, China. Except for polymyxin B, tigecycline, minocycline, cefoperazone/sulbactam, amikacin and levofloxacin, the resistance rates of other antimicrobial agents were above 90%. All the clinical isolates had the bla(OXA-51) gene and 114 isolates had the bla(OXA-23) gene. Forty-nine isolates were found to contain the bla(IMP-4) gene. PFGE data showed that 117 isolates were divided into 25 groups. Sixty-three (53.85%) were found to carry the class 1 integron, and the sequence analysis of the class 1 integron internal variable regions - five types, one of which had the bla(IMP-4) gene. For the bla(IMP-4) positive strain without class 1 integron, we found the flanking sequence had the TnpA gene. The result suggested that the resistance gene was widely distributed in our hospital; moreover, the modes of presence and transmission are different and complicated. The results of our study can improve the infection empirical treatment method and infection control programme.

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