Journal
JOURNAL OF CHEMICAL THERMODYNAMICS
Volume 96, Issue -, Pages 12-23Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jct.2015.11.007
Keywords
Oxiracetam; Solubility; Thermodynamic model; Thermodynamic properties
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Funding
- National Natural Science Foundation of China [NNSFC 21176173, NNSFC 21376164]
- National High Technology Research and Development Program of China [2012AA021202]
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In this paper, we proposed a static analysis method to experimentally determine the (solid + liquid) equilibrium of racemic oxiracetam in (methanol + water), (ethanol + water) and (isopropanol + water) binary solvents with alcohol mole fraction ranging from 0.30 to 0.90 at atmosphere pressure (p = 0.1 MPa). For the experiments, the temperatures range from (283.15 to 308.15) K. The results showed that the solubility of oxiracetam increased with the increasing temperature, while decreased with the increasing organic solvent fraction in all three tested binary solvent systems. The modified Apelblat model, the CNIBS/Redlich-Kister model, the combined version of Jouyban-Acree model and the NRTL model were employed to correlate the measured solubility values, respectively. Additionally, some of the thermodynamic properties which can help to evaluate its dissolution behavior were obtained based on the NRTL model. (C) 2015 Elsevier Ltd. All rights reserved.
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