Journal
JOURNAL OF CHEMICAL THERMODYNAMICS
Volume 94, Issue -, Pages 230-233Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jct.2015.11.019
Keywords
Correlation; Neat solvent; Rosuvastatin calcium; Solubility
Categories
Funding
- King Saud University, Vice Deanship of Research Chairs, Kayyali Chair for Pharmaceutical Industry [FN-2015]
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In the current research work, the solubility of rosuvastatin calcium (ROSCa) in seven different neat solvents such as water, ethanol, 1-butanol, 2-butanol, ethylene glycol (EG), isopropyl alcohol (IPA) and propane-1,2-diol (PG) was measured at five different temperatures i.e. T = (298.15 to 318.15) K and atmospheric pressure. Values of the experimental solubility of ROSCa were correlated with Apelblat and ideal models which showed good correlation and model fitting. The solubility (as mole fraction) of ROSCa was recorded highest in PG (1.89 . 10(-2) at T = 318.15 K) followed by 1-butanol (8.20 . 10(-4) at T = 318.15 K), ethanol (6.81 . 10(-4) at T = 318.15 K), IPA (5.66 . 10(-4) at T = 318.15 K), EG (5.03 . 10(-4) at T = 318.15 K), 2-butanol (1.08 . 10(-4) at T = 318.15 K) and water (1.40 . 10(-5) at T = 318.15 K). The experimental results from this research work would be helpful in the development of conventional and advanced liquid dosage forms of ROSCa. (C) 2015 Elsevier Ltd. All rights reserved.
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