4.1 Article

Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy

Journal

CLINICAL CASE REPORTS
Volume 10, Issue 4, Pages -

Publisher

WILEY
DOI: 10.1002/ccr3.5651

Keywords

depression; hypothyroidism; polymorphism; T3

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We present a case of a 54-year-old man with treatment-resistant depression and hypothyroidism who responded to combination therapy with LT3/LT4, leading to discontinuation of all antidepressant medications. Interestingly, the patient has a DIO2 polymorphism.
We report a 54-year-old man with treatment-resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.

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