Journal
JOURNAL OF CHEMICAL EDUCATION
Volume 93, Issue 8, Pages 1422-1427Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jchemed.5b00891
Keywords
First-Year Undergraduate/General; Green Chemistry; HPLC; Biochemistry; Laboratory Instruction; Inquiry-Based/Discovery Learning Problem Solving/Decision Making Natural Products; Quantitative Analysis; Thin Layer Chromatography
Funding
- Dow Foundation
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In this undergraduate analytical chemistry experiment, students quantitatively assess the antibacterial activity of essential oils found in thyme leaves (Thymus vulgaris) in an authentic, research-like environment. This multiweek experiment aims to instill green chemistry principles as intrinsic to chemical problem solving. Students progress through various techniques including extraction, chromatography (TLC and HPLC), culturing bacteria, and disk diffusion via a process of guided exploration that emphasizes green experimental design. Approximately 600 undergraduate students carried out the experiment and self-reported substantial learning gains.
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