Journal
PHYSIOLOGICAL REPORTS
Volume 10, Issue 5, Pages -Publisher
WILEY
DOI: 10.14814/phy2.15201
Keywords
cardiovascular imaging; COVID-19; inflammation; MIS-C; children
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 88887.509598/2020-00, 303422/2015--7]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo -FAPESP [2015/03756-4, 2019/15231-4, 2017/13552-2]
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This study assessed five post-discharged MIS-C survivors and found that they had impaired MBF, endothelial dysfunction, and lower cardiopulmonary capacity at follow-up analysis.
We assessed PET-CT myocardial blood flow (MBF) using N-13 ammonia, brachial flow-mediated dilation, and cardiopulmonary exercise test in five post-discarged MIS-C survivors. None of the patients (median age: 9, range: 7-18 years; 3 females; 2 males) had preexisting pediatric chronic conditions. At the follow-up visit, two patients exhibited severe perfusion defect developed in the left ventricular cavity, suggesting extensive myocardial ischemia (MBF <2.0) and one patient showed persistent mild pericardial effusion. Others two patients demonstrated endothelial dysfunction. Nevertheless, all patients had lower predicted values in the VO2peak, VO2VAT, OUES, and O-2 Pulse (range: 35.2%-64.5%; 15.6%-38.2%; 1.0-1.3 L/min; 4-7 ml/beat), respectively. Our d suggested that previously health MIS-C patients had impaired MBF, endothelial dysfunction and lower cardiopulmonary capacity at follow-up analysis. Multidisciplinary further investigations should be conducted to reinforce these findings.
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