Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 36, Issue 12, Pages 2051-2057Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X16671317
Keywords
Animal models; brain imaging; cerebral blood flow measurement; intrinsic optical signal imaging; magnesium; optical imaging; spreading depression
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Funding
- NIGMS NIH HHS [P20 GM109089] Funding Source: Medline
- NINDS NIH HHS [R01 NS051288] Funding Source: Medline
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The aim was to characterize the effects of magnesium sulfate, using i.v. bolus and local administration, using intrinsic signal imaging, and on electrocorticographic activity during the induction and propagation of spreading depolarizations in the gyrencephalic porcine brain. Local application of magnesium sulfate led to a complete inhibition of spreading depolarizations. One hour after washing out the topical magnesium sulfate, re-incidence of the spreading depolarizations was observed in 50% of the hemispheres. Those spreading depolarizations showed attenuation in hemodynamic characteristics and speed in intrinsic optical signal imaging. The electrical amplitude decreased through electrocorticographic activity. Intravenous magnesium therapy showed no significant effects on spreading depolarization incidence and characteristics.
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