Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 37, Issue 5, Pages 1748-1762Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X16659496
Keywords
Spreading depolarization; cortical spreading depression; susceptibility; velocity; anisotropy
Categories
Funding
- National Institutes of Health [NS 085413]
- Department of Defense [CDMRP PR 130373]
- National Science Foundation [DMS 0635561]
- National Institutes of Health (Intramural Research Program)
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Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically, apparently not respecting the anatomic, synaptic, functional, or vascular architecture of the brain. However, there is evidence that spreading depolarizations are not truly concentric, isotropic, or homogeneous, either in space or in time. Here we present evidence from KCl-induced spreading depolarizations, in mouse and rat, invivo and invitro, showing the great variability that these depolarizations can exhibit. This variability can help inform the mechanistic understanding of spreading depolarizations, and it has implications for their phenomenology in neurologic disease.
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