Related references
Note: Only part of the references are listed.Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction
Jianzhong Li et al.
SCIENTIFIC REPORTS (2016)
HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-β via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells
Meichu Cheng et al.
AMERICAN JOURNAL OF NEPHROLOGY (2015)
Renal tubular damage may contribute more to acute hyperglycemia induced kidney injury in non-diabetic conscious rats
Jing-Yu Wang et al.
JOURNAL OF DIABETES AND ITS COMPLICATIONS (2015)
Activation of AMPK by metformin inhibits TGF-beta-induced collagen production in mouse renal fibroblasts
Jiamei Lu et al.
LIFE SCIENCES (2015)
Epigenetic regulation in the acute kidney injury to chronic kidney disease transition
Roxana Rodriguez-Romo et al.
NEPHROLOGY (2015)
Metformin Use Reduction in Mild to Moderate Renal Impairment: Possible Inappropriate Curbing of Use Based on Food and Drug Administration Contraindications
James H. Flory et al.
JAMA INTERNAL MEDICINE (2015)
Autophagy in diabetic nephropathy
Yan Ding et al.
JOURNAL OF ENDOCRINOLOGY (2015)
Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis
Hyosang Kim et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)
Autophagy activation reduces renal tubular injury induced by urinary proteins
Wei Jing Liu et al.
AUTOPHAGY (2014)
Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy
Ming-Zhi Zhang et al.
DIABETES (2014)
Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice
Tangli Xiao et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2014)
Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers
Anne-Emilie Decleves et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2014)
Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy
Ying Xu et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2014)
mTOR Signaling in Autophagy Regulation in the Kidney
Ken Inoki
SEMINARS IN NEPHROLOGY (2014)
Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy
Shinji Kume et al.
BIOMED RESEARCH INTERNATIONAL (2014)
Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells
Wei-Qing Han et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Detecting and controlling diabetic nephropathy: What do we know?
Gerald Appel
CLEVELAND CLINIC JOURNAL OF MEDICINE (2013)
Regulation of hypoxia-inducible factor in kidney disease
Masaomi Nangaku et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2013)
Role of Endoplasmic Reticulum Stress in Diabetic Neuropathy
Norman E. Cameron
DIABETES (2013)
Impact of the Hypoxia-Inducible Factor-1 α (HIF1A) Pro582Ser Polymorphism on Diabetes Nephropathy
Harvest F. Gu et al.
DIABETES CARE (2013)
Effect of metformin against cisplatin induced acute renal injury in rats: A biochemical and histoarchitectural evaluation
Bidya Dhar Sahu et al.
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2013)
Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft
Jun Liu et al.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2013)
AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition
Jang Han Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury
Shuya Liu et al.
AUTOPHAGY (2012)
Cellular and molecular mechanisms of metformin: an overview
Benoit Viollet et al.
CLINICAL SCIENCE (2012)
Nutrient Sensing, Autophagy, and Diabetic Nephropathy
Shinji Kume et al.
DIABETES (2012)
Renal Podocyte Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin
Junghyun Kim et al.
EXPERIMENTAL DIABETES RESEARCH (2012)
Metformin Inhibits Advanced Glycation End Products (AGEs)-induced Renal Tubular Cell Injury by Suppressing Reactive Oxygen Species Generation via Reducing Receptor for AGEs (RAGE) Expression
Y. Ishibashi et al.
HORMONE AND METABOLIC RESEARCH (2012)
The role of ATM in response to metformin treatment and activation of AMPK
Sook Wah Yee et al.
NATURE GENETICS (2012)
Activation of AMP-Activated Protein Kinase Inhibits Albumin-Induced Endoplasmic Reticulum Stress and Apoptosis through Inhibition of Reactive Oxygen Species
Eun Kyoung Lee et al.
NEPHRON EXPERIMENTAL NEPHROLOGY (2012)
Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells
Jimmy R. Theriault et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression
Abdulqader A. Alhaider et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2011)
Clinical Pharmacokinetics of Metformin
Garry G. Graham et al.
CLINICAL PHARMACOKINETICS (2011)
Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin A Possible Role of HIF-1α Expression and Oxygen Metabolism
Yumi Takiyama et al.
DIABETES (2011)
Use of Metformin in the Setting of Mild-to-Moderate Renal Insufficiency
Kasia J. Lipska et al.
DIABETES CARE (2011)
Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients
Arpita Chakraborty et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2011)
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
X. Stephenne et al.
DIABETOLOGIA (2011)
Epithelial-mesenchymal transition in renal fibrosis - evidence for and against
Maria Fragiadaki et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2011)
The Tuberin/mTOR Pathway Promotes Apoptosis of Tubular Epithelial Cells in Diabetes
Chakradhar Velagapudi et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells
Zhengchao Wang et al.
KIDNEY INTERNATIONAL (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
Vinita Takiar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Albumin-induced epithelial-mesenchymal transition and ER stress are regulated through a common ROS-c-Src kinase-mTOR pathway: effect of imatinib mesylate
Ji Young Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)
Induction of Diabetes in Aged C57B6 Mice Results in Severe Nephropathy An Association with Oxidative Stress, Endoplasmic Reticulum Stress, and Inflammation
Jin Wu et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway
Xinguo Hou et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Metformin induces suppression of NAD(P)H oxidase activity in podocytes
Agnieszka Piwkowska et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT) From cancer stem cells to aging-associated fibrosis
Silvia Cufi et al.
CELL CYCLE (2010)
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
Adem Kalender et al.
CELL METABOLISM (2010)
Oxidative Stress and Diabetic Complications
Ferdinando Giacco et al.
CIRCULATION RESEARCH (2010)
Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway
Ana I. Morales et al.
KIDNEY INTERNATIONAL (2010)
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Brinda Ravikumar et al.
PHYSIOLOGICAL REVIEWS (2010)
Advanced glycation end products, oxidative stress and diabetic nephropathy
Sho-ichi Yamagishi et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)
The Association of AMPK with ULK1 Regulates Autophagy
Jong Woo Lee et al.
PLOS ONE (2010)
Influence of metformin on GLUT1 gene and protein expression in rat streptozotocindiabetes mellitusmodel
Jelizaveta Sokolovska et al.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2010)
Diabetes mellitus: new challenges and innovative therapies
Cristina M. Sena et al.
EPMA JOURNAL (2010)
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery et al.
CELL (2009)
In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study
Hao Jun et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2009)
The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease
Wilfred Lieberthal et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
Meta-analysis: Metformin treatment in persons at risk for diabetes mellitus
Shelley R. Salpeter et al.
AMERICAN JOURNAL OF MEDICINE (2008)
Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease
Guanghui Liu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Metformin: Effects on micro and macrovascular complications in type 2 diabetes
Clifford J. Bailey
CARDIOVASCULAR DRUGS AND THERAPY (2008)
Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia A nested case-control analysis
Michael Bodmer et al.
DIABETES CARE (2008)
Proteinuria and Hyperglycemia Induce Endoplasmic Reticulum Stress
Maja T. Lindenmeyer et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Stabilization of HIF-1α is critical to improve wound healing in diabetic mice
Ileana Ruxandra Botusan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine
Mingyan Zhou et al.
DRUG METABOLISM AND DISPOSITION (2007)
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
Yan Shu et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy
Myung-Ja Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
Benoit Viollet et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
AMP-activated protein kinase signaling in metabolic regulation
Yun Chau Long et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice
M Sakaguchi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw et al.
SCIENCE (2005)
The pathobiology of diabetic complications - A unifying mechanism
M Brownlee
DIABETES (2005)
Role of reactive oxygen species in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
DY Rhyu et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)
Comparative outcomes study of metformin intervention versus conventional approach - The COSMIC approach study
DR Cryer et al.
DIABETES CARE (2005)
New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology
G Wolf
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2004)
Oxidative stress mediates apoptotic changes induced by hyperglycemia in human tubular kidney cells
D Verzola et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)
Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention
YH Liu
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus - Systematic review and meta-analysis
SR Salpeter et al.
ARCHIVES OF INTERNAL MEDICINE (2003)
Role of advanced glycation end products in diabetic nephropathy
JM Forbes et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)