Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 231, Issue 11, Pages 2333-2338Publisher
WILEY
DOI: 10.1002/jcp.25363
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Funding
- Tulane Center for Aging
- NIH [5-P20GM103629-04, CA125806]
- NSF [1258536]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1258536] Funding Source: National Science Foundation
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Investigation into the mechanisms driving cancer cell behavior and the subsequent development of novel targeted therapeutics requires comprehensive experimental models that mimic the complexity of the tumor microenvironment. Recently, our laboratories have combined a novel tissue culture model and laser direct-write, a form of bioprinting, to spatially position single or clustered cancer cells onto ex vivo microvascular networks containing blood vessels, lymphatic vessels, and interstitial cell populations. Herein, we highlight this new model as a tool for quantifying cancer cell motility and effects on angiogenesis and lymphangiogenesis in an intact network that matches the complexity of a real tissue. Application of our proposed methodology offers an innovative ex vivo tissue perspective for evaluating the effects of gene expression and targeted molecular therapies on cancer cell migration and invasion. (C) 2016 Wiley Periodicals, Inc.
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