Journal
MATERIALS TODAY ADVANCES
Volume 14, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtadv.2022.100229
Keywords
Porphyrin; Photodynamic therapy; Photothermal therapy; Metallacycle
Categories
Funding
- Project of Sci-ence and Technology Commission of Shanghai Municipality [21ZR1417800]
- National Natural Science Foundation of China [21875063]
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This study presents a multifunctional platform for synergistic photochemotherapy using metallacycle-based star polymers and gold nanorods, which demonstrates high therapeutic efficacy and negligible side effects.
Although platinum-based anticancer drugs have prevailed in traditional chemotherapy, the severe side effects and drug resistance hampered their clinical applications. Combinational therapies have exhibited promises in antitumor treatments. However, the integration of different anticancer modalities is often challenging because of the conflicts between maximal synergy of therapeutic effects and reduction of side effects. Here, we report a multifunctional platform composed of metallacycle-based star polymer and gold nanorods for synergistic photochemotherapy. We applied the Pt-based metallacycle-cored star polymers as both a photodynamic photosensitizer and a Pt-based anticancer drug. The gold nanorods play the dual role of photothermal converter and energy acceptor of fluorescence resonance energy transfer effect from the star polymers. The photothermal effect enhanced tumor permeability of reactive oxygen species and Pt-based drug molecules and the photodynamic effect destructed heat shock proteins to prevent the mechanism of cellular self-protection response to heat. This mutually beneficial strategy results in high therapeutic efficacy and negligible side effects verified by both in vitro and in vivo studies. This study offers a new avenue in designing a multifunctional platform for the synergy of different antitumor modalities. (c) 2022 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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