Journal
MATERIALS TODAY BIO
Volume 15, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtbio.2022.100298
Keywords
pH sensor; Lactate sensor; Batteryless device; Near field communication; Central venous catheter; Totally implanted access port
Funding
- Engineering and Physical Sciences Research Council [EP/L014149/1, EP/P012779]
- Wellcome Trust Funding Programme in the United Kingdom [WTiTPA PSZ088]
Ask authors/readers for more resources
Totally implanted access ports (TIAP) are widely used for long term central venous access in oncology patients. This paper proposes a smart TIAP device that can detect infection and monitor biomarkers in body fluids to provide vital information about the patient's health and potential port infection.
Totally implanted access ports (TIAP) are widely used with oncology patients requiring long term central venous access for the delivery of chemotherapeutic agents, infusions, transfusions, blood sample collection and parenteral nutrition. Such devices offer a significant improvement to the quality of life for patients and reduced complication rates, particularly infection, in contrast to the classical central venous catheters. Nevertheless, infections do occur, with biofilm formation bringing difficulties to the treatment of infection-related complications that can ultimately lead to the explantation of the device. A smart TIAP device that is sensor-enabled to detect infection prior to extensive biofilm formation would reduce the cases for potential device explantation, whereas biomarkers detection within body fluids such as pH or lactate would provide vital information regarding metabolic processes occurring inside the body. In this paper, we propose a novel batteryless and wireless device suitable for the interrogation of such markers in an embodiment model of an TIAP, with miniature biochemical sensing needles. Device readings can be carried out by a smartphone equipped with Near Field Communication (NFC) interface at relative short distances off-body, while providing radiofrequency energy harvesting capability to the TIAP, useful for assessing patient's health and potential port infection on demand.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available