4.3 Article

Survey of US Oncologists Practices and Beliefs Regarding DPYD Testing Before Fluoropyrimidine Chemotherapy

Related references

Note: Only part of the references are listed.
Article Oncology

Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines

P. Garcia-Alfonso et al.

Summary: Genotyping DPYD gene polymorphisms before administering fluoropyrimidines can help classify individuals as normal, intermediate, or poor metabolizers, allowing for personalized treatment strategies to avoid toxicities. The consensus aims to provide clear recommendations for implementing genotype and/or phenotype testing for DPD deficiency in cancer patients receiving fluoropyrimidines.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

Article Pharmacology & Pharmacy

Patients carrying DPYD variant alleles have increased risk of severe toxicity and related treatment modifications during fluoropyrimidine chemotherapy

Faisal Shakeel et al.

Summary: This study evaluated the toxicity risk in carriers of four DPYD variants using an institutional genetic repository, confirming that patients carrying these variants are at increased risk of severe toxicity or subsequent treatment modifications. The results suggest that genotype-informed treatment may benefit patients with DPYD variants, highlighting the importance of genetic information in guiding chemotherapy treatment decisions.

PHARMACOGENOMICS (2021)

Editorial Material Genetics & Heredity

Expanding evidence leads to new pharmacogenomics payer coverage

Philip E. Empey et al.

GENETICS IN MEDICINE (2021)

Review Oncology

Pathogenic DPYD Variants and Treatment-Related Mortality in Patients Receiving Fluoropyrimidine Chemotherapy: A Systematic Review and Meta-Analysis

Bhavina B. Sharma et al.

Summary: This study systematically evaluated the risk of treatment-related death associated with DPYD gene variants during fluoropyrimidine chemotherapy, and found that patients with pathogenic DPYD gene variants have a significantly increased risk of treatment-related death.

ONCOLOGIST (2021)

Article Biochemistry & Molecular Biology

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of DPYD and fluoropyrimidines

Carin A. T. C. Lunenburg et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2020)

Article Genetics & Heredity

Knowledge and attitudes on pharmacogenetics among pediatricians

Shahad Rahawi et al.

JOURNAL OF HUMAN GENETICS (2020)

Editorial Material Oncology

Including DPYD on Cancer Genetic Panels to Prevent Fatal Fluoropyrimidine Toxicity COMMENT

Daniel L. Hertz et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Review Pharmacology & Pharmacy

DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report

Theodore J. Wigle et al.

PHARMACEUTICS (2019)

Article Oncology

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis

Maarten J. Deenen et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Article Oncology

DPYD Variants as Predictors of 5-fluorouracil Toxicity in Adjuvant Colon Cancer Treatment (NCCTG N0147)

Adam M. Lee et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

Article Pharmacology & Pharmacy

Cancer pharmacogenomics, adoption by oncologists and patient benefit

Lynn G. Dressler et al.

PERSONALIZED MEDICINE (2014)

Article Pharmacology & Pharmacy

Adoption of Pharmacogenomic Testing by US Physicians: Results of a Nationwide Survey

E. J. Stanek et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)