Journal
INTERNATIONAL JOURNAL OF BIOPRINTING
Volume 8, Issue 2, Pages 95-108Publisher
WHIOCE PUBL PTE LTD
DOI: 10.18063/ijb.v8i2.549
Keywords
Vesicoureteral reflux; Double-J stent; 3D printing; Anti-reflux diode; Urology; bladder-ureter junction (vesicoureteric junction [VUJ])
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT of the Republic of Korea [NRF2021R1C1C1010836]
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This paper presents novel umbrella-shaped flexible devices for preventing vesicoureteral reflux, particularly in patients with urinary stones. The devices mechanically attach to the stent and have been shown to be effective through experiments. The penta-shaped device exhibited the best anti-reflux performance, with maximum efficiency achieved when attached at a specific location.
This paper presents novel umbrella-shaped flexible devices to prevent vesicoureteral reflux along double-J stents, which is a backward flow of urine from the bladder to the kidney and is a critical issue in patients with urinary stones. The anti-reflux devices were designed to mechanically attach to the stent and were manufactured using three-dimensional (3D) printing and polymer casting methods. Based on the umbrella shapes, four different devices were manufactured, and the antireflux efficiency was demonstrated through in vitro experiments using a urination model. Consequently, penta-shaped devices exhibited the best anti-reflux performance (44% decrease in reflux compared to the stent without the device), and maximum efficiency occurred when the device was attached near the bladder-ureter junction. In addition, a disadvantage of 3D printing (i.e., unwanted rough surface) helped the device strongly adhere to the surface of the stent during the insertion operation. Finally, long-term soaking experiments revealed that the fabricated devices were mechanically robust and chemically stable (safe) even being soaked in urine for 4 weeks. The findings of this study support the use of additive manufacturing to make various flexible and biocompatible urological devices to mitigate critical issues in patients with urinary stones.
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