Journal
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
Volume 7, Issue 1, Pages 554-566Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2021.12.010
Keywords
Saccharomyces cerevisiae; Synthetic biology; Metabolic engineering; Biofuels; Redox metabolism; Energy metabolism
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Funding
- DSM Bio-based Products & Services B.V. (Delft, The Netherlands)
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This paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of Saccharomyces cerevisiae. It discusses the context dependency, theoretical impact, and potential for industrial application of different strategies.
Product yield on carbohydrate feedstocks is a key performance indicator for industrial ethanol production with the yeast Saccharomyces cerevisiae. This paper reviews pathway engineering strategies for improving ethanol yield on glucose and/or sucrose in anaerobic cultures of this yeast by altering the ratio of ethanol production, yeast growth and glycerol formation. Particular attention is paid to strategies aimed at altering energy coupling of alcoholic fermentation and to strategies for altering redox-cofactor coupling in carbon and nitrogen metabolism that aim to reduce or eliminate the role of glycerol formation in anaerobic redox metabolism. In addition to providing an overview of scientific advances we discuss context dependency, theoretical impact and potential for industrial application of different proposed and developed strategies.
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