Drug delivery of paracetamol by metal-organic frameworks (HKUST-1): improvised synthesis and investigations

Magnetic drug delivery acts as an efficient method for carrying a drug directly to an organ or targeted location in the body by incorporating magnetically vulnerable material coated with a drug-laden matrix. Magnetic nanoparticles of MOF acts as a drug carrier by targeting the treatment location without affecting the other cells. In this view, the synthesis of the porous flexible Cu-based metal-organic framework (MOF), Cu-BTC (BTC, benzene tricarboxylic acid), also known as HKUST-1 has been examined. The crystalline growth has been optimized through improvised hydrothermal technique profiles using non-toxic solvents. Structural properties were investigated using X-ray diffraction spectroscopy, Scanning electron microscopy, and Fourier-transform infrared spectroscopy. X-ray absorption spectra at O and C K-edges along with Cu L-edge to affirm the electronic structure in the optimized sample. The yield of the reaction was 72% and 80% for chemical and hydrothermal techniques, respectively. The experiment was carried out by taking 3.5 ppm as an optimized concentration of paracetamol, where HKUST-1 (1 mg) sample was added into the solution and, a small amount of sample was withdrawn at certain time intervals, whose absorbance was checked using UV-Visible spectroscopy. The investigated kinetics was proposed to generalize the drug delivery technique using bio-compatible MOFs. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

Magnetic drug delivery is an efficient method to transport drugs directly to organs or targeted locations in the body. The study examines the Cu-BTC (HKUST-1) MOF as a drug carrier through optimized crystalline growth and structural properties. The results suggest that this drug delivery technique using bio-compatible MOFs is effective.