Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 25, Issue 44, Pages 6927-6935Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201502811
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Funding
- Natural Science Foundation of China [21137002]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB14030401]
- Advanced Materials Transformational Capability Platform in CSIRO
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Nanomaterials are used increasingly in diagnostics and therapeutics, particularly for malignancies. Efficient targeting of nanoparticles to specific cells is an important requirement for the development of successful nanoparticle-based theranostics and personalized medicines. Gold nanoparticles are surface modified using a library of small organic molecules, and optionally folate, to investigate their ability to target four cell lines from common cancers, three having high levels of folate receptors expression. Uptake of these nanoparticles varies widely with surface chemistriy and cell lines. Sparse machine learning methods are used to computationally model surface chemistry-uptake relationships, to make quantitative predictions of uptake for new nanoparticle surface chemistries, and to elucidate molecular aspects of the interactions. The combination of combinatorial surface chemistry modification and machine learning models will facilitate the rapid development of targeted theranostics.
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