Journal
MATERIALS TODAY CHEMISTRY
Volume 23, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mtchem.2021.100637
Keywords
Transferrin; Drug delivery; Magnetic targeting ability; Blood-brain barriers
Funding
- National Natural Science Foundation of China [U1703118]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [19KJA310003]
- Natural Science Foundation of Jiangsu Province [BK20181364]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Shuangchuang Program, China
- Science and Technology Development Fund of Nanjing Medical University [NMUB2020006]
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Exosomes are utilized as drug nanocarriers, and a convenient extraction and targeted delivery is achieved through magnetism, showing potential for treating brain diseases.
Exosomes possess endogenous attributes and distinct biological functions, and thereby, their uses as drug nanocarriers have attracted increasing attention for biomedical practices. However, to achieve targeted therapeutic purposes, complicated extractions, as well as modifications of exosomes, are involved. Here, based on the use of superparamagnetic iron oxide nanoparticles conjugated exosome (Ex-SPIONs), a facile exosome extraction through magnetism was established. The produced Ex-SPIONs exhibited a uniform size distribution and desirable biocompatibility. Moreover, taking advantage of the magnetic properties of SPIONs, the targeted delivery of Ex-SPIONs was demonstrated in the rat brain. Therefore, the constructed SPIONs functionalized exosome shows promising therapeutic potentials, including the treatment of brain diseases. (c) 2021 Elsevier Ltd. All rights reserved.
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