6-Month Evaluation of a Transcatheter Aortic Valve (Myval) in a Novel Ovine, Supra-Aortic Banding Model

The aim of the study was to evaluate a balloon expandable transcatheter heart valve (THV) system (Myval) at 6-month follow-up in ovine banding model. Eleven THV systems were implanted via carotid approach. There were 2 procedure-related deaths and 2 premature deaths. At 6 months all valves that completed follow-up (n = 7) were functional, with no significant regurgitation, calcification, thrombi, or vegetation. Mean pressure gradient was 21.9 ?? 11 mm Hg, maximum velocity = 3.3 ?? 1 m/s, and ejection fraction was 53.3 ?? 6%. Myval THV showed optimal hemodynamic performance and biocompatibility. (J Am Coll Cardiol Basic Trans Science 2022;7:486???495) ?? 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

The study evaluated a balloon expandable transcatheter heart valve system in an ovine banding model. The results showed that the valve system had good functionality and biocompatibility.