Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 117, Issue 10, Pages 2370-2376Publisher
WILEY-BLACKWELL
DOI: 10.1002/jcb.25534
Keywords
FATTY ACID COMPOSITION; BONE MARROW FLUID; BONE MARROW MICROENVIROMENT; OSTEOPOROSIS; HIP FRACTURE
Categories
Funding
- Fondo Nacional de Ciencia y Tecnologia (FONDECYT) [1130045]
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Bone marrow adipose tissue (BMAT) is associated with low bone mass, although the functional consequences for skeletal maintenance of increased BMAT are currently unclear. BMAT might have a role in systemic energy metabolism, and could be an energy source as well as an endocrine organ for neighboring bone cells, releasing cytokines, adipokines and free fatty acids into the bone marrow microenvironment. The aim of the present report was to compare the fatty acid composition in the bone marrow supernatant fluid (BMSF) and blood plasma of postmenopausal women women (65-80 years old). BMSF was obtained after spinning the aspirated bone marrow samples; donors were classified as control, osteopenic or osteoporotic after dual-energy X-ray absorptiometry. Total lipids from human bone marrow fluid and plasma were extracted, converted to the corresponding methyl esters, and finally analyzed by a gas chromatographer coupled with a mass spectrometer. Results showed that fatty acid composition in BMSF was dynamic and distinct from blood plasma, implying significance in the locally produced lipids. The fatty acid composition in the BMSF was enriched in saturated fatty acid and decreased in unsaturated fatty acids as compared to blood plasma, but this relationship switched in women who suffered a hip fracture. On the other hand, there was no relationship between BMSF and bone mineral density. In conclusion, lipid composition of BMSF is distinct from the circulatory compartment, most likely reflecting the energy needs of the marrow compartment. J. Cell. Biochem. 117: 2370-2376, 2016. (c) 2016 Wiley Periodicals, Inc. Fatty acid composition in bone marrow fluid and blood plasma is different. The fatty acid composition in the bone marrow supernatant fluid switched in women who suffered a hip fracture.
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