Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 20, Issue 9, Pages 1779-1788Publisher
WILEY
DOI: 10.1111/jcmm.12861
Keywords
Let-7 miRNAs; regulatory loops; non-coding RNAs; cancer stem cells; DNA methylation; anti-cancer research; clinical application
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Funding
- National Natural Science Foundation of China [81272418]
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The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.
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